Journal
AUTOPHAGY
Volume 3, Issue 1, Pages 35-37Publisher
LANDES BIOSCIENCE
DOI: 10.4161/auto.3311
Keywords
pexophagy; vacuole; peroxisomes; phosphoinositides; sterol
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We recently showed that, in the yeast Pichia, pastoris, an ergosterol glucoside synthesizing enzyme, Atg26, is recruited to the precursor of the pexophagic structure, micropexophogic membrane apparatus (MIPA), under the regulation of phosphatidylinositol 4'-monophosphate (PI4P)-signaling during pexophagy. Atg26 was found to harbor a novel PI4-binding motif, the GRAM domain. Both lipids, PI4P and sterol glucoside, synthesized by PpPik1 and PpAtg26, respectively, were necessary for pexophagy, in the step where the MIPA was formed. In this addendum, we review these findings, and speculate on the mechanistic and physiological implications of the functions of these lipids during the autophagic process.
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