Journal
INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY
Volume 142, Issue 2, Pages 127-132Publisher
KARGER
DOI: 10.1159/000096438
Keywords
vitamin C; vitamin E; tryptophan; neopterin; kynurenine; indoleamine-(2,3)-dioxygenase
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Background/Aims: The antioxidant properties of vitamin C and E are considered to be important for their anti-inflammatory activity. Recently, antioxidant resveratrol was found to suppress neopterin production and tryptophan degradation in mitogen-treated human peripheral blood mononuclear cells. Methods: In this study, the effects of vitamin C and E were investigated in unstimulated peripheral blood mononuclear cells and in cells stimulated with the mitogens phytohaemagglutinin and concanavalin A in vitro. Results: The mitogens induced a significant production of neopterin and a degradation of tryptophan. Vitamin C (0.1-10 mu M) and E (5-100 mu M) suppressed these immunobiological pathways in a dose-dependent way (p < 0.01). Conclusion: Neopterin production and tryptophan degradation in monocyte-derived macrophages are both triggered by the pro-inflammatory cytokine interferon-gamma. Thus, their concurrent suppression by vitamin C and E suggests an effect on the formation and release of this cytokine by stimulated T cells. These findings may be related to the general health benefits which are associated with the antioxidant nature of these vitamins. Copyright (c) 2007 S. Karger AG, Basel
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