Journal
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
Volume 11, Issue 5, Pages 1185-1207Publisher
WILEY
DOI: 10.1111/j.1582-4934.2007.00098.x
Keywords
deleted in liver cancer; GTPase activating protein; tumour suppressor; metastasis suppressor; cytoskeletal organization; tensin; focal adhesion; cancer detection; cancer therapy
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Funding
- Intramural NIH HHS Funding Source: Medline
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The deleted in liver cancer 1 (DLC-1) gene encodes a GTPase activating protein that acts as a negative regulator of the Rho family of small GTPases. Rho proteins transduce signals that influence cell morphology and physiology, and their aberrant up-regulation is a key factor in the neoplastic process, including metastasis. Since its discovery, compelling evidence has accumulated that demonstrates a role for DLC-1 as a bona fide tumour suppressor gene in different types of human cancer. Loss of DLC-1 expression mediated by genetic and epigenetic mechanisms has been associated with the development of many human cancers, and restoration of DLC-1 expression inhibited the growth of tumour cells in vivo and in vitro. Two closely related genes, DLC-2 and DLC-3, may also be tumour suppressors. This review presents the current status of progress in understanding the biological functions of DLC-1 and its relatives and their roles in neoplasia.
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