Journal
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
Volume 11, Issue 5, Pages 958-968Publisher
WILEY
DOI: 10.1111/j.1582-4934.2007.00107.x
Keywords
interstitial cells of Cajal; calcium oscillations; smooth muscle; voltage-gated Ca2+ channels; non-selective cation channels; transient receptor potential (TRP) homologues; Ca2+-activated Cl- channels; inositol trisphosphate receptors; ryanodine receptors; c-Kit
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A considerable body of evidence has revealed that interstitial cells of Cajal (ICC), identified with c-Kit-immunoreactivity, act as gut pacemaker cells, with spontaneous Ca2+ activity in ICC as the probable primary mechanism. Namely, intracellular (cytosolic) Ca2+ oscillations in ICC periodically activate plasmalemmal Ca2+-dependent ion channels and thereby generate pacemaker potentials. This review will, thus, focus on Ca2+-associated mechanisms in ICC in the gastrointestinal (GI) tract, including auxiliary organs.
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