Journal
EXPERT REVIEW OF MEDICAL DEVICES
Volume 4, Issue 5, Pages 605-614Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1586/17434440.4.5.605
Keywords
deep brain stimulation; device; frequency modulation; local field potentials; nonlinear correlation; Parkinson's disease
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The analysis of neural rhythms measured in local field potentials (LFPs) through deep brain stimulation (DBS) electrodes have provided a new insight into brain mechanisms of information processing. The application of novel methodological approaches for UP analysis is of key importance to uncover the complexity of such mechanisms, thereby clarifying the relationship between the LFP code and patient's clinical state. Thanks to a new device for recording artifact-free LFPs during high-frequency stimulation, DBS-induced neural rhythms modulations and their nonlinear features can be analyzed and used in the development of a new, adaptive DBS approach: the frequency, strength and site of DBS could be controlled, in a closed-loop system, through LFP-based variables obtained through the application of different methodological approaches.
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