Journal
EXPERT OPINION ON DRUG DISCOVERY
Volume 2, Issue 9, Pages 1225-1240Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1517/17460441.2.9.1225
Keywords
biomarkers; gene expression profiling; microarrays; neuroprotective multifunctional drugs; Parkinson's disease; rasagiline
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It is recognised that in both genetic and sporadic cases of Parkinson's disease (PD), the basis of its etiopathology resides in the particular vulnerability of the dopaminergic neurons of the substantia nigra pars compacta (SNpc) to oxidative stress and in the failure to adequately remove abnormal proteins. These observations have been confirmed recently by microarray transcriptomic studies in human SN from PD brains and have extended understanding of the molecular pathways underlying the PD pathology. This article reviews recent gene expression profiling studies in sporadic PD postmortem SN and highlights gene candidates as putative molecular signatures for early disease diagnosis. In addition, the application of transcriptomics and proteomics in the quest for multifunctional neuroprotective-neurorescue drugs that might possess disease-modifying action is discussed.
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