Journal
MINI-REVIEWS IN MEDICINAL CHEMISTRY
Volume 7, Issue 9, Pages 877-887Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/138955707781662618
Keywords
PPAR gamma ligands; cancer; immune system; cell cycle; apoptosis; TZDs; myeloid neoplasms; lymphoid neoplasms
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PPAR gamma has emerged as a key regulator of cell growth and survival, whose activity is modulated by a number of synthetic and natural ligands. Here we shall review the activities of PPAR gamma ligands in the control of immune cell proliferation, differentiation and apoptosis and their potential therapeutic applications to hematological malignancies.
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