Journal
CURRENT OPINION IN IMMUNOLOGY
Volume 19, Issue 3, Pages 365-372Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.coi.2007.04.004
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The original definition of NK cells was based on their 'natural' cytolytic response against tumor cells and virus-infected cells in the absence of specific immunization. However, the term,natural killer' reflects neither the education/maturation requirements before NK cells can kill nor the entirety of their biological functions. In light of new functional assays, genetic models and genomics analysis, we propose a more accurate definition of NK cells. This definition includes the phenotypical identification of NK cells as CD3(-)NKp46(+) cells across mammalian species. In general, this attempt to redefine NK cells also highlights the need to update the operational definition of cell types in the post-genomic area.
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