Journal
JOURNAL OF CONSULTING AND CLINICAL PSYCHOLOGY
Volume 75, Issue 3, Pages 475-488Publisher
AMER PSYCHOLOGICAL ASSOC
DOI: 10.1037/0022-006X.75.3.475
Keywords
depression; relapse and recurrence; cognitive-behavioral therapy; continuation and maintenance treatment; meta-analysis
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Funding
- NATIONAL INSTITUTE OF MENTAL HEALTH [K24MH001571, R01MH058397, K02MH001571] Funding Source: NIH RePORTER
- NIMH NIH HHS [MH-01571, R01 MH058397, K24 MH001571, K24 MH001571-07, R01 MH058397-07, K02 MH001571, MH-58397] Funding Source: Medline
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Relapse and recurrence following response to acute-phase treatment for major depressive disorder (MDD) are prevalent and costly. In a meta-analysis of 28 studies including 1,880 adults, the authors reviewed the world's published literature on cognitive-behavioral therapies (CT) aimed at preventing relapse-recurrence in MDD. Results indicate that after discontinuation of acute-phase treatment, many responders to CT relapse-recur (29% within 1 year and 54% within 2 years). These rates appear comparable to those associated with other depression-specific psychotherapies but lower than those associated with pharmacotherapy. Among acute-phase treatment responders, continuation-phase CT reduced relapse-recurrence compared with assessment only at the end of continuation treatment (21% reduction) and at follow-up (29% reduction). Continuation-phase CT also reduced relapse-recurrence compared with other active continuation treatments at the end of continuation treatment (12% reduction) and at follow-up (14% reduction). The authors discuss implications for research and patient care and suggest directions, with methodological refinements, for future studies.
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