Journal
CURRENT OPINION IN IMMUNOLOGY
Volume 19, Issue 2, Pages 203-208Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.coi.2007.02.001
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Funding
- NCI NIH HHS [CA107527, CA43059, K08 CA128893] Funding Source: Medline
- NATIONAL CANCER INSTITUTE [R01CA107527, R37CA043059, K08CA128893, R01CA043059] Funding Source: NIH RePORTER
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When immune cells and developing tumor cells localize to a common microenvironment, an assemblage of interactions takes place; this results in either tumor destruction by way of immunosurveillance or tumor outgrowth. These events put a functional imprint onto the emerging tumor repertoire because tumor cells arising in the presence of a fully functional immune system are less immunogenic than those that develop in the absence of immunity (i.e. in RAG2(-/-) and perforin(-/-) mice). However, other studies suggest that the immune system can also actively promote formation of certain tumors. These apparent disparate effects of immunity on tumorigenesis provide a,unique model for study of the decision-making process that dictates immune function within a tumor.
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