Journal
CURRENT OPINION IN IMMUNOLOGY
Volume 19, Issue 2, Pages 163-168Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.coi.2007.02.011
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In vivo, T cells develop in the thymus from bone marrow-derived hematopoietic progenitors. Similarly, T cells can develop in vitro in model systems that mimic thymic function. The recent development of the OP9-DL1 cell culture system, a two-dimensional T-inductive environment, has provided greater access to the processes of commitment and development in T lymphocytes.
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