Journal
EXPERT OPINION ON THERAPEUTIC TARGETS
Volume 11, Issue 4, Pages 453-461Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1517/14728222.11.4.453
Keywords
gynecologic malignancy; M1 aininopeptidase; P-LAP; prognosis
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The M1 aminopeptidase family is important for the maturation or degradation of bioactive peptides by hydrolyzing their N-terminal amino acids. Some investigators have studied aminopeptidase in the maintenance of homeostasis including maintenance of normal pregnancy, memory retention, blood pressure regulation and antigen presentation. However, there are a few reports on the relation between the M1 aminopeptidase family and carcinoma. in addition to its capacity to degrade a range of peptides, placental-leucine aminopeptidase (P-LAP) has novel functions that impact on normal cells and neoplastic cells. P-LAP is the focus of this review.
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