Journal
CURRENT OPINION IN IMMUNOLOGY
Volume 19, Issue 2, Pages 123-128Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.coi.2007.02.007
Keywords
-
Categories
Funding
- ICREA Funding Source: Custom
- NATIONAL CANCER INSTITUTE [R01CA089590] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [R01NS043881] Funding Source: NIH RePORTER
- NCI NIH HHS [R01 CA89590-01] Funding Source: Medline
- NINDS NIH HHS [R01 NS43881-01] Funding Source: Medline
Ask authors/readers for more resources
Recent research suggests that lymphoid progenitors in the bone marrow comprise a heterogeneous cell population. This population first loses megakaryocyte/erythroid, and then granulocyte/macrophage, potential before committing to lymphoid lineages. B and T cells can originate by way of different pathways that appear to be used with varying frequencies in the animal. In the bone marrow, B cell specification and commitment is driven by the concerted action of transcription factors and IL-7 signaling. In the thymus, multipotent progenitors become committed to the T-cell lineage through the action of Notch1. The activated intracellular form of Notch1 suppresses transcription factors that can instruct myeloid cell fates, thereby directly coupling extracellular signaling with changes in transcriptional networks. In conclusion, although a lot is known about B and T cell commitment, more work needs to be done to clarify the earliest steps in lymphoid specification.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available