Journal
CANCER LETTERS
Volume 349, Issue 1, Pages 87-94Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2014.03.029
Keywords
Antisense RNA; Long noncoding RNA; Tumor growth; RNA hybridazation; RNA stability
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Funding
- Chinese Key Project for Infectious Diseases [2012ZX10002010, 2012ZX10002016]
- Science Fund for Creative Research Groups, NSFC, China [81221061]
- National Natural Science Foundation of China [81071681, 81372207]
- Shanghai Rising-Star Program [12QA1404900]
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About 61-72% of transcribed regions possess long noncoding RNAs in antisense orientation (Antisense long noncoding RNAs, asIncRNAs). However, the function of aslncRNAs in HCC remains unclear. We found numerous aslncRNAs were deregulated and might be involved in regulatory gene-net of HCC. The PCNA-AS1, antisense to PCNA, is significantly up-regulated in HCC and could promote tumor growth in vitro and in vivo. The effects of PCNA-AS1 rely on regulation of PCNA via forming RNA hybridization to increase PCNA mRNA stability. We concluded that asIncRNAs might act as upstream regulators in HCC and PCNA-AS1 could serve as a novel therapeutic target. (C) 2014 Elsevier Ireland Ltd. All rights reserved.
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