Journal
CANCER LETTERS
Volume 347, Issue 2, Pages 225-232Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2014.02.013
Keywords
LSD1; Pancreatic cancer; Glycolysis; HIF1 alpha
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Funding
- National Science Foundation of China [81372651, 81201900]
- Chinesisch-Deutsches Forschungsprojekt [GZ 857]
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The histone demethylase LSD1 (lysine specific demethylase 1) plays an important role in the epigenetic regulation of gene transcription. Our study investigated the role of LSD1 in pancreatic cancer and demonstrated that LSD1 was significantly up-regulated in pancreatic cancer patient tissue samples, and elevated LSD1 protein levels positively correlated with overall survival of pancreatic cancer patients. Using in vitro and in vivo models, we demonstrated that knock-down of LSD1 repressed proliferation and tumorigenicity of pancreatic cancer cells. Mechanistically, our study demonstrated that LSD1 synergized with HIFI a (hypoxia inducible factor-1 alpha) in maintaining glycolytic process, which fueled pancreatic cancer uncontrolled proliferation. (C) 2014 Elsevier Ireland Ltd. All rights reserved.
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