Journal
CANCER LETTERS
Volume 351, Issue 1, Pages 13-22Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2014.05.002
Keywords
Cancer therapy; Peptide; Anticancer mechanism; Modification strategy
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Funding
- National Natural Science Foundation of China [81273228, 81172893]
- Foundation of Science & Technology Department of Henan Province, China [132300410012]
- Excellent Youth Foundation of Henan Province, China [134100510015]
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Cancer is one of the leading causes of death worldwide. Conventional cancer therapies mainly focus on mass cell killing without high specificity and often cause severe side effects and toxicities. Peptides are a novel class of anticancer agents that could specifically target cancer cells with lower toxicity to normal tissues, which will offer new opportunities for cancer prevention and treatment. Anticancer peptides face several therapeutic challenges. In this review, we present the sources and mechanisms of anticancer peptides and further discuss modification strategies to improve the anticancer effects of bioactive peptides. (C) 2014 Elsevier Ireland Ltd. All rights reserved.
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