Journal
CANCER LETTERS
Volume 344, Issue 2, Pages 239-259Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2013.11.001
Keywords
Plumbagin; Non-small-cell lung cancer; Apoptosis; Autophagy; PI3K/Akt/mTOR
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Funding
- College of Pharmacy, University of South Florida, Tampa, FL
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Plumbagin (PLB) has shown anti-cancer activity but the mechanism is unclear. This study has found that PLB has a potent pro-apoptotic and pro-autophagic effect on A549 and H23 cells. PLB arrests cells in G2/M phase, and increases the intracellular level of reactive oxygen species in both cell lines. PLB dose-dependently induces autophagy through inhibition of PI3K/Akt/mTOR pathway as indicated by reduced phosphorylation of Akt and mTOR. Inhibition or induction of autophagy enhances PLB-induced apoptosis. There is crosstalk between PLB-induced apoptosis and autophagy. These findings indicate that PLB initiates both apoptosis and autophagy in NSCLC cells through coordinated pathways. (C) 2013 Elsevier Ireland Ltd. All rights reserved.
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