Journal
ACTA BIOCHIMICA ET BIOPHYSICA SINICA
Volume 39, Issue 3, Pages 155-162Publisher
OXFORD UNIV PRESS
DOI: 10.1111/j.1745-7270.2007.00263.x
Keywords
influenza A virus; NS1A protein; RNA-binding domain; effector domain; dimer; resistance; antiviral response
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The avian influenza A virus currently prevailing in Asia causes fatal pneumonia and multiple organ failure in birds and humans. Despite intensive research, understanding of the characteristics of influenza A virus that determine its virulence is incomplete. NS1A protein, a non-structural protein of influenza A virus, was reported to contribute to its pathogenicity and virulence. NS1A protein is a multifunctional protein that plays a significant role in resisting the host antiviral response during the influenza infection. This review briefly outlines the current knowledge on the structure and function of the NS1A protein.
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