Journal
CANCER LETTERS
Volume 342, Issue 1, Pages 27-35Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2013.08.033
Keywords
Gastric cancer; MiR-215; Retinoblastoma; Proliferation
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Funding
- Natural Scientific Foundation of China [31071221, 31190063, 31125017, 31100975]
- Ministry of Science and Technology of China [2013CB945603, 2012CB945004, 2011CBA01001]
- Ministry of Education of China [20110101110103]
- Natural Scientific Foundation of Zhejiang Province, China [LQ13H160013, Z2100247, Y2100106]
- 111 Project [B13026]
- Department of Science and Technology of Zhejiang Province [2009C03012-3, 2009F80005]
- Zhejiang Provincial Program for the Cultivation of High-level Innovative Health talents
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Growing evidence indicates that miRNAs play critical roles in tumorigenesis and cancer progression. Here, we report that miR-215 is significantly up-regulated in gastric cancer tissues from either gastrectomy or gastroscopy. Receiver Operator Characteristic (ROC) curve analysis indicated that miR-215 may be a candidate biomarker for gastric cancer diagnosis. Inhibition of miR-215 significantly suppressed gastric cancer cell proliferation possibly via G1 arrest. Further analyses indicated that miR-215 was able to target retinoblastoma tumor-suppressor gene 1 (RB1) through its 3'-UTR in gastric cancer cells. These data suggest that frequently up-regulated miR-215 in gastric cancer may influence cell proliferation by targeting RB1. (C) 2013 Elsevier Ireland Ltd. All rights reserved.
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