Journal
MOLECULAR PSYCHIATRY
Volume 12, Issue 3, Pages 247-257Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/sj.mp.4001926
Keywords
depression; meta-analysis; 5-HTTLPR; polymorphism; treatment response; SSRI
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The serotonin transporter gene promoter polymorphism (5-HTTLPR) has been repeatedly associated with antidepressant response in mood disorder patients, but findings are not consistent across studies. A meta-analysis was performed on 15 studies including data of 1435 subjects. We tested three phenotypes: remission rate, response rate and response rate within 4 weeks using the cochrane review manager. We observed a significant association of the s/s variant of 5-HTTLPR with remission rate (P < 0.0001) and both s/s and s/l variants with response rate ( P = 0.0002). Response rate within 4 weeks was associated in both models (P = 0.003 - P < 0.00001). This effect is quite robust to ethnic differences although a significant heterogeneity is present in Asian samples.
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