Journal
CANCER LETTERS
Volume 354, Issue 2, Pages 447-454Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2014.08.018
Keywords
Mycoplasma hyorhinis; EMT; NF-kappa B; TLR4; Gastric cancer
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Funding
- National Natural Science Foundation of China [91029713]
- National Basic Research Program of China [2010CB529303]
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Our previous works showed chronic infection of Mycoplasma hyorhinis (M. hyorhinis) was associated with gastric cancer metastasis, but the mechanisms were unknown. Herein, we found M. hyorhinis induced epithelial-mesenchymal transition (EMT) in gastric cancer cell MGC803, which was counteracted by inhibitor of NF-kappa B signaling or p65 knockdown. Furthermore, we found that TLR4 associated with p37, a membrane protein of M. hyorhinis. Knock-down or inhibition of TLR4 antagonized M. hyorhinis-induced NF-kappa B signaling, EMT, and cell migration. Thus, M. hyorhinis induces EMT and promotes cell migration via TLR4-NF-kappa B signaling, which provides a clue to the pathogenesis of M. hyorhinis in gastric cancer. (C) 2014 Elsevier Ireland Ltd. All rights reserved.
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