Journal
CANCER LETTERS
Volume 344, Issue 1, Pages 28-39Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2013.10.036
Keywords
S100A4; Tumor-stroma interactions; Metastasis; Cytokines; Melanoma
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Funding
- Norwegian Cancer Society
- Jeanette and Soren Bothners Legacy
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Tumor cells have the ability to exploit stromal cells to facilitate metastasis. By using malignant melanoma as a model, we show that the stroma adjacent to metastatic lesions is enriched in the known metastasis-promoting protein S100A4. S100A4 stimulates cancer cells to secrete paracrine factors, such as inflammatory cytokines 18, CCL2 and SAA, which activate stromal cells (endothelial cells and monocytes) so that they acquire tumor-supportive properties. Our data establishes S1 00A4 as an inducer of a cytokine network enabling tumor cells to engage angiogenic and inflammatory stromal cells, which might contribute to pro-metastatic activity of S100A4. (C) 2013 Elsevier Ireland Ltd. All rights reserved.
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