Journal
CANCER LETTERS
Volume 353, Issue 2, Pages 145-152Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2014.07.047
Keywords
Mesenchymal stem cells; Lung cancer; Microenvironment
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Funding
- National Natural Science Foundation of China [81301812, 81172233]
- Specialized Research Fund for the Doctoral Program of Higher Education [20131202120004]
- Scientific Research Foundation for the Returned Overseas Chinese Scholars of State Education Ministry, Tianjin Educational Committee Foundation [20120117]
- Wu Jieping Medical Foundation [320.6750.1377, 320.6750.1376, 320.6750.12341]
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The tumor microenvironment (TME) of lung cancer has been documented to play an important role in participating in tumor disease progression. As the precursor of most stroma in TME, mesenchymal stem cells (MSCs) draw great attention since evidence has suggested that MSCs derived from lung cancer patients present a different phenotype compared to their normal counterparts. Furthermore, MSCs could be recruited towards tumor sites and influence tumor survival, although the effect remains contradictory. Our review will summarize the current advance of the role MSCs in lung cancer and explore the possible treatment strategies by blocking their crosstalk. (C) 2014 Elsevier Ireland Ltd. All rights reserved.
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