Journal
CANCER LETTERS
Volume 353, Issue 2, Pages 153-159Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2014.06.022
Keywords
Triple negative breast cancer; Cancer stem cells; CD44(+)/CD24(-)
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Funding
- PUMC Youth Fund [2012129]
- Open Research Fund of the State Key Laboratory of Molecular Oncology [SKL-KF-2010-03]
- National Natural Scientific Foundation of China [81000991, 30973447]
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The mechanism underlying the aggressive behaviors of triple negative breast cancer (TNBC) is not well characterized yet. The association between cancer stem cell (CSC) population and the aggressive behaviors of TNBC has not been established. We found the CD44(+)/CD24(-) cell population was enriched in TNBC tissues and cell lines, with a higher capacity of proliferation, migration, invasion and tumorigenicity as well as lower adhesion ability. The CD44(+)/CD24(-) cell population with cancer stem cell-like properties may play an important role in the aggressive behaviors of TNBC. This discovery may lead to new therapeutic strategies targeting CD44(+)/CD24(-) cell population in TNBC. (C) 2014 Elsevier Ireland Ltd. All rights reserved.
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