Journal
CANCER LETTERS
Volume 338, Issue 1, Pages 47-56Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2012.06.013
Keywords
Epithelial-to-mesenchymal transition; HNSCC; Cancer stem(-like) cells; MicroRNA; Metastasis; Therapeutic target regulation
Categories
Funding
- Oracle Cancer Trust
- ZAST-organization
- Charite-Universitatsmedizin
- Berliner Krebsgesellschaft e.V.
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Head and neck squamous cell carcinoma (HNSCC) is the 6th commonest cancer worldwide. Relapse, thought to involve cancer stem(-like) cells (CSCs), and the development of metastases are common and survival rates remain low. Epithelial-to-mesenchymal transition (EMT) is a key event in metastasis and increasing evidence suggests a link between EMT and CSCs. MicroRNAs regulate multiple cellular processes including EMT and have been implicated in a CSC phenotype. This review aims to highlight key events that are involved in EMT, discusses their relevance in HNSCC progression and metastasis and explores the possibility of targeting EMT as a novel therapy in HNSCC. (C) 2012 Elsevier Ireland Ltd. All rights reserved.
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