Journal
CANCER LETTERS
Volume 331, Issue 2, Pages 167-173Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2012.12.026
Keywords
Neuroblastoma; SL7207; Dendritic cells; Gene gun; Lentiviral particle
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Funding
- German-Research Foundation, DFG [Fe 914/2-1]
- Walter-Schulz-Foundation
- HEXAL (Barleben, Sachsen-Anhalt)
- Kind-Philipp-Foundation
- Medical Faculty, Otto-von-Guericke University
- BMBF within the ENGINE consortium
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Attenuated Salmonella is an approved oral life vaccine that is currently entering pre-clinical cancer vaccination studies as a promising DNA carrier. In a syngeneic mouse model for neuroblastoma, oral gavage of Salmonella typhimurium (SL7207) carrying recent generated survivin DNA vaccines induced a stronger cellular anti-NB immune response than gene gun application or injection of lentivirally transduced bone marrow-derived DCs. The level of Salmonella-associated side effects was not significant as indicated by unaffected survivin-mediated hematopoiesis and wound healing. We believe that our findings provide an important baseline to translate Salmonella-based DNA vaccination into a clinical application for neuroblastoma. (C) 2013 Elsevier Ireland Ltd. All rights reserved.
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