Journal
CANCER LETTERS
Volume 336, Issue 2, Pages 379-389Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2013.03.027
Keywords
SOX2; Tumor metastasis; EMT; beta-catenin; TGF-beta 1
Categories
Funding
- China 973 Program [2013CB967201]
- NSFC [31000616, 81273331]
- China International Cooperation Research Program [2012DFA10650]
- China Junior Faculty Funds [20090031120044]
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SOX2 was reported to promote metastasis in various tumor tissues; however the underlying mechanisms remain elusive. Here, we disclosed that SOX2 improves metastasis of breast and prostate cancer cells by promoting epithelial-to-mesenchymal transition (EMT) through WNT/beta-catenin, but not TGF-beta or Snaill signaling. Dual luciferase assay and chromatin immunoprecipitation revealed activation and binding of SOX2 on promoter region of beta-catenin. In addition, SOX2 affects the protein expression levels of DKK3, DVL1 and DVL3, which are regulators or downstream molecules of WNT signaling. Taken together, our findings demonstrated beta-catenin as one of vital downstream molecules that mediate the EMT induced by SOX2. (C) 2013 Elsevier Ireland Ltd. All rights reserved.
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