Journal
CANCER LETTERS
Volume 335, Issue 1, Pages 93-99Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2013.02.006
Keywords
Sonodynamic therapy; 5-Aminolevulinic acid; Anti-angiogenesis; Anti-tumor
Categories
Funding
- National Natural Science Foundation of China [81272503]
- Scientific and Technical Key Tasks of Heilongjiang Province, China [GC10C306]
Ask authors/readers for more resources
Studies of sonodynamic therapy (SDT) have mainly focused on its direct cytotoxic effect on tumor cells. Its effects on the tumor microenvironment, especially angiogenesis, remain unknown. In this study, we found that SDT significantly inhibited endothelial cell proliferation, migration, invasion, and tube formation. Furthermore, in a tumor xenograft mouse model, SDT was found to remarkably suppress tumor growth, intratumoral vascularity, and expression of vascular endothelial growth factor in tumor cells. An ultrastructural study showed damage and disruption of tumor microvasculature after STD. Our results indicate that SDT inhibits neovascularization in tumor, which is partially responsible for the anti-tumor effect of SDT. (c) 2013 Elsevier Ireland Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available