Journal
CANCER LETTERS
Volume 336, Issue 1, Pages 46-52Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2013.04.008
Keywords
PIWI-interacting RNAs; Cancer; Diagnosis; Therapy
Categories
Funding
- National Cancer Institute [R01 CA126818, R01 CA136635]
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Piwi-interacting RNAs (piRNAs), a newly identified class of small non-coding RNAs, direct the Piwi-dependent transposon silencing, heterochromatin modification and germ cell maintenance. Owing to our limited knowledge regarding their biogenesis, piRNAs are considered as the most mysterious class of small regulatory RNAs, particularly in pathogenesis such as tumorigenesis. Recently, several lines of evidence have emerged to suggest that piRNAs may be dis-regulated and play crucial roles in tumorigenesis in previously unsuspected ways. In this prospective piece, we will discuss the emerging insights into the potential novel roles of piRNAs in carcinogenesis and highlight their potential implications in cancer detection, classification and therapy. (C) 2013 Elsevier Ireland Ltd. All rights reserved.
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