Journal
CANCER LETTERS
Volume 330, Issue 1, Pages 1-10Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2012.11.038
Keywords
Visceral fat; Cancer; Colorectal cancer; Oesophageal adenocarcinoma; Pancreatic cancer; Hepatocellular carcinoma
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Funding
- Sydney West Translational Cancer Research Fellowship
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There is emerging evidence that the association between obesity and cancer is mediated by visceral rather than generalised body fat. Visceral fat has been directly implicated in the risk and progression of several gastrointestinal cancers including colorectal, oesophageal, pancreatic and hepatocellular carcinomas. Excess visceral adipose tissue induces a state of chronic systemic inflammation and altered metabolic activity that promotes a pro-oncogenic environment. This review examines the evidence linking visceral fat in gastrointestinal and hepatic carcinogenesis and explores our current understanding of the mechanisms underlying this relationship. (C) 2012 Elsevier Ireland Ltd. All rights reserved.
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