Journal
COORDINATION CHEMISTRY REVIEWS
Volume 251, Issue 1-2, Pages 234-254Publisher
ELSEVIER SCIENCE SA
DOI: 10.1016/j.ccr.2006.07.018
Keywords
As-III; As-V; Se-IV; Se-VI; Hg2+; metabolism; endogenous thiols; antagonism; mechanism of chronic toxicity; environmental bioinorganic chemistry
Categories
Ask authors/readers for more resources
When rabbits are simultaneous injected with arsenite and selenite or mercuric chloride and selenite, compounds with As-Se and Hg-Se bonds are formed in the bloodstream. The combined application of liquid chromatography-inductively coupled plasma atomic emission spectrometry (ICP-AES) and X-ray absorption spectroscopy (XAS) has revealed the molecular structure of these toxicologically important compounds and provided insight into their mechanism of formation. The glutathione-driven formation of these compounds in the bloodstream fundamentally links the metabolism of the environmental pollutants mercuric mercury and arsenite with that of the essential ultratrace element selenium, which establishes a feasible mechanism by which the chronic low-level exposure of various human populations to these toxic metals and metalloid compounds is linked to human diseases, including cancer and neurodegenerative diseases. (c) 2006 Elsevier B.V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available