Journal
CANCER LETTERS
Volume 329, Issue 1, Pages 84-90Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2012.10.019
Keywords
Colorectal cancer; MiR-429; Prognosis; Apoptosis; SOX2
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Funding
- National Natural Science Foundation of China [30672010]
- Shandong Province Natural Science Foundation of China [ZR2010H004, ZR2009CQ038]
- National Key Clinical Medical Specialties Foundation
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Emerging evidence has demonstrated that microRNAs (miRNAs) can act as oncogenes or tumor suppressors to participate in cancer development. In this study, we found that miR-429 expression was up-regulated in human colorectal cancer (CRC) tissues, and the high miR-429 expression was significantly associated with tumor size, lymph node metastasis and poor prognosis. Functionally, miR-429 overexpression suppressed cell apoptosis by directly targeting SOX2 in HT-29 cells. Taken together, our data suggest for the first time that miR-429 could play an oncogenic role in the cellular processes of CRC and represent a novel prognostic biomarker for CRC. (c) 2012 Elsevier Ireland Ltd. All rights reserved.
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