Journal
CANCER LETTERS
Volume 331, Issue 1, Pages 24-34Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2013.01.010
Keywords
Apoptosis; Bcl-2; Cancer; IAP; Melanoma
Categories
Funding
- National Science Centre [2011/01/B/NZ4/04921]
Ask authors/readers for more resources
Apoptosis plays a pivotal role in sustaining proper tissue development and homeostasis. Evading apoptosis by cancer cells is a part of their adaption to microenvironment and therapies. Cellular integrity is predominantly maintained by pro-survival members of Bcl-2 family and IAPs. Melanoma cells are characterized by a labile and stage-dependent phenotype. Pro-survival molecules can protect melanoma cells from apoptosis and mediate other processes, thus enhancing aggressive phenotype. The essential role of Bcl-2, Mcl-1, Bcl-X-L, livin, survivin and XIAP was implicated for melanoma, often in a tumor stage-dependent fashion. In this review, the current knowledge of pro-survival machinery in melanoma is discussed. (C) 2013 Elsevier Ireland Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available