Journal
CANCER LETTERS
Volume 335, Issue 2, Pages 380-386Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2013.02.054
Keywords
EMMPRIN/CD147; Cancer-associated fibroblasts; Epithelial-to-mesenchymal transition; alpha-SMA; Cancer stroma
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Funding
- US Department of Defense [W81XWH-11-1-0107]
- Breast Cancer Research Foundation
- China National Basic Research Program (the 973 Program) award [2009CB521704]
- China National Natural Science Foundation [30800573]
- NIH through MD Anderson's Cancer Center [CA016672]
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We tested the novel hypothesis that EMMPRIN/CD147, a transmembrane glycoprotein overexpressed in breast cancer cells, has a previously unknown role in transforming fibroblasts to cancer-associated fibroblasts, and that cancer-associated fibroblasts in turn induce epithelial-to-mesenchymal transition of breast cancer cells. Co-culture of fibroblasts with breast cancer cells or treatment of fibroblasts with breast cancer cell conditioned culture medium or recombinant EMMPRIN/CD147 induced expression of alpha-SMA in the fibroblasts in an EMMPRIN/CD147-dependent manner and promoted epithelial-to-mesenchymal transition of breast cancer cells and enhanced cell migration potential. These findings support a novel role of EMMPRIN/CD147 in regulating the interaction between cancer and stroma. (C) 2013 Elsevier Ireland Ltd. All rights reserved.
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