Journal
CANCER LETTERS
Volume 337, Issue 2, Pages 285-292Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2013.04.025
Keywords
CD147; ABCG2; Chemoresistance; Breast cancer
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Funding
- National Natural Science Foundation For Distinguished Young Scholars of China [81225013]
- National Natural Science Foundation of China [81071290, 81000690, 81001217, 81101654]
- Millions of Strategic Project of Xiang Ya Hospital
- Freedom Explore Program of Central South University
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CD147 and ABCG2 both have been reported to mediate Multidrug resistance (MDR) in breast cancer. Recent study demonstrates that CD147 could form a complex with ABCG2 on the cell membrane in primary effusion lymphoma. However, whether these two molecules regulate each other in breast cancer and result in MDR is not clear. We established four MCF-7 cell lines transfected with CD147 and/or ABCG2 and found that CD147 could increase the expression and dimerization of ABCG2, affect its cellular localization and regulate its drug transporter function. The findings derived from cells were confirmed subsequently in clinic samples of chemotherapy-sensitive/resistant breast cancer. (C) 2013 Elsevier Ireland Ltd. All rights reserved.
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