Journal
CANCER LETTERS
Volume 333, Issue 2, Pages 253-260Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2013.01.039
Keywords
miR-143; Glioblastoma stem-like cells; Glycolysis; Neurosphere; 2-Deoxy-D-glucose (2-DG)
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Funding
- National Natural Science Foundations of China [30901533, 81172388, 30973078, 81272788]
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Glioblastomas rely mainly on aerobic glycolysis to sustain proliferation and growth; however, little is known about the regulatory mechanisms of metabolism in glioblastoma stem cells. We show that miR-143 is significantly down-regulated in glioma tissues and glioblastoma stem-like cells (GSLCs), while miR-143 over-expression inhibits glycolysis by directly targeting hexokinase 2, and promotes differentiation of GSLCs. Moreover, miR-143 inhibits proliferation of GSLCs under hypoxic conditions and decreases tumor formation capacity of GSLCs in vivo. We also show that a combination of miR-143 and 2-DG, a widely used glycolysis inhibitor, has synergistic effects against GSLCs. miR-143 is a potential therapeutic target for glioblastoma treatment. (C) 2013 Elsevier Ireland Ltd. All rights reserved.
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