Journal
CANCER LETTERS
Volume 341, Issue 1, Pages 80-96Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2013.01.042
Keywords
Cell plasticity; Microenvironment; Cell motility; Hypoxia; Acidity; Extracellular matrix
Categories
Funding
- Associazione Italiana Ricerca sul Cancro (AIRC)
- Istituto Toscano Tumori and Regione Toscana (TUMAR)
Ask authors/readers for more resources
Cancer cells undergo genetic changes allowing their adaptation to environmental changes, thereby obtaining an advantage during the long metastatic route, disseminated of several changes in the surrounding environment. In particular, plasticity in cell motility, mainly due to epigenetic regulation of cancer cells by environmental insults, engage adaptive strategies aimed essentially to survive in hostile milieu, thereby escaping adverse sites. This review is focused on tumor microenvironment as a collection of structural and cellular elements promoting plasticity and adaptive programs. We analyze the role of extracellular matrix stiffness, hypoxia, nutrient deprivation, acidity, as well as different cell populations of tumor microenvironment. (C) 2013 Elsevier Ireland Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available