Journal
HUMAN BRAIN MAPPING
Volume 28, Issue 1, Pages 34-48Publisher
WILEY-BLACKWELL
DOI: 10.1002/hbm.20254
Keywords
anatomy; cross-sectional; brain mapping; frontal lobe; anatomy and histology; image processing; computer-assisted; neuroanatomy; atlases
Funding
- MRC [G9805989, G108/585] Funding Source: UKRI
- Medical Research Council [G108/585, G9805989] Funding Source: Medline
Ask authors/readers for more resources
We manually defined the inferior frontal gyrus (IFG) on high-resolution MRIs, in native space in 30 healthy subjects (15 female, median age 31 years; 15 male, median age 30 years), resulting in 30 individual atlases. Using standard software (SPM99), these were spatially transformed to a widely used stereotaxic space (MNI/ICBM 152) to create probabilistic maps. In native space, the total IFG volume was on average 5%, and the gray matter (GM) portion 12% larger in women (not significant). Expressed as a percentage of ipsilateral frontal lobe volume (i.e., correcting for brain size), the IFG was an average of 20%, and the GM portion of the IFG 27%, larger in women (P < 0.005). Correcting for total lobar volume yielded the same result. No asymmetry was found in IFG volumes. There were significant positional differences between the right and left IFGs, with the right IFG being further lateral in both native and stereotaxic space. Variability was similar on the left and right, but more pronounced anteriorly and superiorly. We show differences in IFG volume, composition, and position between sexes and between hemispheres. Applications include probabilistic determination of location in group studies, automatic labeling of new scans, and detection of anatomical abnormalities in patients.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available