Journal
CANCER LETTERS
Volume 335, Issue 1, Pages 242-250Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2013.02.034
Keywords
Cervical cancer; E6; p53; Gene therapy; Attenuated Salmonella typhimurium
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Funding
- National Natural Science Foundation of China [30801354, 30970791, 81201188]
- US National Institutes of Health [CA 105005]
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The E6 protein of the oncogenic HPV-16 functions by interfering with the normal cell cycle control mechanisms, particularly those controlled by p53. In this study, we developed a dual expression plasmid that coexpressed-E6-specific siRNA and wild type p53, and to evaluate its effects on cervical cancer growth. We found that simultaneous expression of pSi-E6-P53 caused a robust suppression of tumor growth when compared to the controls either E6-specific siRNA or p53 alone. In conclusion, our findings demonstrate that a combined strategy of co-expressed E6-specific siRNA and p53 synergistically and more effectively suppressed cervical tumor growth when compared with single treatment. (c) 2013 Elsevier Ireland Ltd. All rights reserved.
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