Journal
CANCER LETTERS
Volume 331, Issue 1, Pages 1-10Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2012.12.006
Keywords
miRNA; Transcriptional regulation; Transcription machinery; Epigenetic regulation; Cancer
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Funding
- National Basic Research Program of China (973 Program) [2010CB912800]
- National Natural Science Foundation of China [PC: 81001023]
- Research Grants Council of Hong Kong [467109, 470911]
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MicroRNAs (miRNAs) are members of non-coding RNAs. They are involved in diverse biological functions. MiRNAs are precisely regulated in a tissue- and developmental-specific manner, but dysregulated in many human diseases, in particular cancers. Transcriptional regulation, post-transcriptional regulation, as well as genetic alterations, are the three major mechanisms controlling the spatial and temporal expression of miRNAs. Emerging evidence now indicates that transcriptional and epigenetic regulations play major roles in miRNA expression. This review summarizes the current knowledge and discusses the future challenges. (C) 2012 Elsevier Ireland Ltd. All rights reserved.
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