Journal
CANCER LETTERS
Volume 331, Issue 2, Pages 174-182Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2012.12.021
Keywords
AIDS; Primary effusion lymphoma; V gamma 9V delta 2 T cell; Zoledronic acid
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Funding
- Ministry of Health, Labour, and Welfare of Japan [H22-AIDS-I-002]
- Global COE program, Global Education and Research Center Aiming at the Control of AIDS
- Kumamoto University Advance Research Project A, International Research Center for Development of Therapy and Vaccine for AIDS
- Ministry of Education, Science, Sports, and Culture of Japan [23107725]
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Primary effusion lymphoma (PEL) is a subtype of aggressive and resistant non-Hodgkin lymphoma that occurs predominantly in patients with advanced AIDS. In this study, we examined the antitumor activity of zoledronic acid (Zol)-induced V gamma 9V delta 2 T cells against PEL cells in vitro and in vivo. V gamma 9V delta 2 T cells recognized endogenous mevalonate metabolites and MICA/B of PEL cell lines, inducing cytotoxicity via granule exocytosis and TRAIL-mediated pathway. V gamma 9V delta 2 T cells suppressed the development of PEL cells and existed in a PEL xenograft mouse model. These results show that immunotherapy with Zol-induced V gamma 9V delta 2 T cells could demonstrate an efficient strategy for PEL. (C) 2013 Elsevier Ireland Ltd. All rights reserved.
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