Journal
CANCER LETTERS
Volume 331, Issue 1, Pages 46-51Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2012.11.012
Keywords
R249S; Hepatitis B virus; Hepatocellularcarcinoma; HBX
Categories
Funding
- IARC
- Ligue contre le Cancer, Departement du Rhone, France
Ask authors/readers for more resources
Hepatocellular carcinoma (HCC) is associated with hepatitis B virus (HBV) chronicity and dietary exposure to aflatoxin, a mutagen targeting codon 249 of tumor suppressor TP53 (R249S mutation). Based on a case-control in Thailand, we have measured R249S and the status of HBX gene in plasma DNA of 176 cases and 133 referents. Detection of HBX complete sequences was associated with R249S in HCC with no documented prior cirrhosis but not in HCC developing in a context of cirrhosis or in non-cancer chronic liver diseases. Thus, R249S may specifically cooperate with HBX in a pathway to HCC that bypasses cirrhosis. (C) 2012 Elsevier Ireland Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available