Journal
CANCER LETTERS
Volume 316, Issue 2, Pages 126-131Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2011.10.040
Keywords
Angiogenesis; Erythropoietin; Intussusceptive microvascular growth; Tumor growth; Vascular endothelial growth factor
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Funding
- AIRC, Milan, Italy
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Intussusception is an alternative to the sprouting mode of angiogenesis. The advantage of this mechanism of vascular growth is that blood vessels are generated more rapidly and the capillaries thereby formed are less leaky. This review article summarizes our current knowledge concerning the role played by intussusceptive microvascular growth in tumor growth. Interestingly, an angiogenic switch from sprouting to intussusceptive angiogenesis occurs after treatment with angiogenesis inhibitors and may be considered as a tumor-protective adaptative response. (C) 2011 Elsevier Ireland Ltd. All rights reserved.
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