Journal
CANCER LETTERS
Volume 325, Issue 1, Pages 11-17Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2012.05.031
Keywords
MAGE; p53; Transcriptional inhibition; Anticancer therapies
Categories
Funding
- UBACyT
- AIRC [IG4752]
- PRIN [2006053543_003]
- FBB fellowship
- CONICET PhD fellowships
- Area Science Park
- [PICT07-00283]
- [PIP-674]
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Since its discovery in 1991, the knowledge about the tumor specific melanoma antigen gene (MAGE-I) family has been continuously increasing. Initially. MAGE-I proteins were considered as selective targets for immunotherapy. More recently, emerging data obtained from different cellular mechanisms controlled by MACE-I proteins suggest a key role in the regulation of important pathways linked to cell proliferation. This is in part due to the ability of some MAGE-I proteins to control the p53 tumor suppressor. In this review, we focus on the mechanisms proposed to explain how MAGE-I proteins affect p53 functions. (C) 2012 Elsevier Ireland Ltd. All rights reserved.
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