Journal
CANCER LETTERS
Volume 321, Issue 2, Pages 110-119Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2012.01.040
Keywords
Mucins; Toll-like receptors; Infection; Inflammation; Cancer
Categories
Funding
- Department of Defence [BC074639, BC083295, BC09742]
- National Institutes of Health [RO1 CA78590, UO1 CA111294, RO1 CA133774, RO1 CA131944, P50 CA127297, U54 CA163160]
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Inflammation is underlying biological phenomenon common in infection and cancer. Mucins are glycoproteins which establish a physical barrier for undesirable entry of foreign materials through epithelial surfaces. A deregulated expression and an anomalous glycosylation pattern of mucins are known in large number of cancers. TLRs are class of receptors which recognize the molecular patterns of invading pathogens and activate complex inflammatory pathways to clear them. Aberrant expression of TLRs is observed in many cancers. A highly orchestrated action of mucins and TLRs is well evolved host defence mechanism; however, a link between the two in other non-infectious conditions has received less attention. Here we present an overview as to how mucins and TLRs give protection to the host and are deregulated during carcinogenesis. Further, we propose the possible mechanisms of cross-regulation between them in pathogenesis of cancer. As both mucins and TLRs are therapeutically important class of molecules, an understanding of the underlying molecular mechanisms connecting the two will open new avenues for the therapeutic targeting of cancer. (c) 2012 Elsevier Ireland Ltd. All rights reserved.
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