Journal
CANCER LETTERS
Volume 315, Issue 2, Pages 122-128Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2011.07.021
Keywords
Carnosine; Cell growth; Reactive Oxygen Species; Glycolysis
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Carnosine is a natural dipeptide that has generated particular interest for its antioxidant, anti-aging and especially for its antiproliferative properties. In this study, we demonstrate that carnosine inhibits the proliferation of human HCT116 colon cancer cells. In this cell line, the activating KRAS mutation induces mitochondrial ROS, the signaling molecules for cell proliferation. We observed that 50-100 mM carnosine decreases ATP and ROS concentration and induces cell cycle arrest in G1 phase. In HCT116 cells these effects are related to decreased ERK1/2 phosphorylation and increased p21(waf1) protein. Our findings support the concept that carnosine could inhibit HCT116 cell growth via its antioxidant activity and its ability to affect glycolysis. (C) 2011 Elsevier Ireland Ltd. All rights reserved.
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