Journal
CANCER LETTERS
Volume 316, Issue 1, Pages 23-30Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2011.10.013
Keywords
Midkine; Osteosarcoma; Lung metastasis; Cell proliferation; Anti-midkine antibody
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Funding
- Grants-in-Aid for Scientific Research [23790091] Funding Source: KAKEN
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Midkine (MK) plays important roles in tumorigenesis, however, the biological function of MK and whether MK can be a therapeutic target in osteosarcoma are unclear. Here, we found that osteosarcoma tissues showed high MK expression. MK knockdown by small interfering RNA significantly induced apoptosis in osteosarcoma cells, whereas recombinant MK increased cell proliferation. Inhibition of MK signaling by anti-MK monoclonal antibody (anti-MK mAb) suppressed growth of osteosarcoma cells both in vitro and in vivo. Moreover, inhibition of MK function significantly suppressed lung metastasis in xenograft transplantation model. Targeting MK by anti-MK mAb may have value in the treatment of osteosarcoma. (C) 2011 Elsevier Ireland Ltd. All rights reserved.
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