Journal
GENE EXPRESSION PATTERNS
Volume 7, Issue 1-2, Pages 187-196Publisher
ELSEVIER
DOI: 10.1016/j.modgep.2006.07.002
Keywords
atypical protein kinase C; signal transduction; mouse embryogenesis; RNA in situ hybridization
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The atypical C-type protein kinases (aPKCs) comprise the third subclass of the PKC family functionally defined by insensitivity to phorbol esters, diacylgylcerol and calcium. aPKCs have been implicated in numerous biological processes including cell proliferation and survival, cell polarity, migration and inflammation. However, only insufficient data exist with regard to aPKC isoform specificity, since both mammalian aPKCs, PKCi/lambda and PKC zeta, exhibit a high structural homology and very similar biochemical properties. In this study, we therefore used isoform-specific riboprobes and antibodies to define the characteristic expression profile of each aPKC isoform during mouse embryogenesis. Both, PKCi/lambda and zeta show highly specific temporal and spatial patterns of expression which may help in distinguishing physiological functions of these isoforms. (c) 2006 Elsevier B.V. All rights reserved.
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