Journal
FOOD ADDITIVES AND CONTAMINANTS PART A-CHEMISTRY ANALYSIS CONTROL EXPOSURE & RISK ASSESSMENT
Volume 24, Issue -, Pages 122-135Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/02652030701393112
Keywords
furan; methylfuran; ascorbic acid; model systems; food; labelled precursors; mechanistic study; SPME-GC/MS; isotope dilution assay
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Previous model studies have suggested ascorbic acid as one of the major sources of furan, a possibly hazardous compound found in thermally processed foods (e.g. canned products, jars). The study showed that about 2 mmol mol(-1) furan was obtained when dry-heating ascorbic acid, while much lower amounts were formed upon pressure cooking, i.e. 58 mu mol mol(-1) at pH 4 and 3.7 mu mol mol(-1) at pH 7. Model reactions also generated 2-methylfuran (MF). However, the MF levels were generally very low with the exception of the binary mixture ascorbic acid/phenylalanine (1 mmol mol(-1)). Studies with 13 C-labelled ascorbic acid indicated that furan comprises an intact C-4 unit, mainly C-3 to C-6, generated by splitting off two C, units, i.e. CO2 and formic acid. Possible intermediates are 2-deoxyaldoteroses, 2-furoic acid and 2-furaldehyde, which are known as ascorbic acid degradation products. The mechanism of furan formation from ascorbic acid was validated based on the labelling pattern of furan and the identification of (CO2)-C-13 and (HCOOH)-C-13. Furan formation is significantly slowed down in binary mixtures, e.g. the presence of erythrose led to 80% less furan under roasting conditions. This is most likely due to competing reactions in complex systems, thus disfavouring furan formation. The mitigation effect is because furan, contrary to MF, is formed without recombination of ascorbic acid fragments. Therefore, furan levels are definitely much lower in foods than expected from trials with pure ascorbic acid. Consequently, conclusions should be drawn with much caution from model reactions, avoiding extrapolation from oversimplified model systems to food products.
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