Journal
CANCER LETTERS
Volume 317, Issue 2, Pages 207-217Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2011.11.026
Keywords
Ovarian cancer; Cancer cell invasion; Vasculogenic mimicry; Stat3; Rho; IGF; IGF-IR
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Funding
- Ministere de l'Enseignement Superieur et de la Recherche
- Ligue Departementale de l'Eure contre le Cancer
- Association Ti'toine
- Groupement des Entreprises Francaises dans la Lutte contre le Cancer de Rouen (GEFLUC of Rouen)
- Ligue Regionale de Haute Normandie contre le Cancer
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Seeking to improve ovarian cancer therapy, we compared biological characteristics of the moderately-aggressive OVCAR-3 cell line with two highly aggressive ovarian cancer cell populations: the SK-OV-3 cell line, and HASCJ primary cells isolated from the ascitic fluid of a patient with FIGO stage IV ovarian cancer. Secretion of angiogenic factors was not discriminative, whereas cell invasion through Matrigel and vasculogenic mimicry were much greater in the more aggressive cells. Among 10 agents tested for their ability to decrease cancer cell aggressivity using these two models, inhibitors of Stat3, IGF-IR and Rho GTPase were found to be the most promising. (C) 2011 Elsevier Ireland Ltd. All rights reserved.
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